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KMID : 1040620170230040273
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Clinical and Molecular Hepatology
2017 Volume.23 No. 4 p.273 ~ p.279
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Treatment options after sorafenib failure in patients with hepatocellular carcinoma
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Dika Imane El
Abou-Alfa Ghassan K.
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Abstract
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Second line therapy after failure of sorafenib continues to be under study. Prognosis of hepatocellular carcinoma is measured in months, with median overall survival reaching 10.7 months with sorafenib. Because of the modest net benefit sorafenib has contributed, and rising incidence of hepatocellular carcinoma in the world, continued efforts are ongoing to look for efficient upfront, second line, or combination therapies. Herein we review the most relevant to date published literature on treatment options beyond sorafenib, reported studies, ongoing investigational efforts, and possibilities for future studies in advanced hepatocellular carcinoma.
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KEYWORD
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Hepatocellular carcinoma, Antiangiogenic therapy, MET-inhibitors, Immunotherapy
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